Evaluation of 7 techniques for the quantification of myocardial oedema in STEMI

Background Myocardial oedema is a consequence of injury during ST segment elevation myocardial infarction (STEMI). T2 weighted short tau inversion recovery (T2w STIR) is widely used for oedema assessment on CMR. No consensus exits for which threshold/ contouring method should be used for the quantification of the area of myocardial oedema as a surrogate endpoint in clinical trials. This study investigates the interand intraobserver and interscan reproducibility of 7 techniques in use for oedema assessment (2 SD, 3 SD, 5 SD, FWHM, Otsu, manual threshold and manual contouring). The aim was to determine the most robust method for the quantification of myocardial oedema STEMI.